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Institute by Medical (US) Committee on Assessing Interactions Among Sociable, Behavioral, and Genetic Factors in Health; Hernandez LM, Blazer DG, editors. Disease, Behavior, and the Social Environment: Movers Beyond the Nature/Nurture Debate. Washington (DC): National Academies Push (US); 2006.

Cover of Genes, Behavior, and the Social Green

Genes, Behavioral, and the Social Surround: Moving Out this Nature/Nurture Debate.

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2To Impact of Social and Cultural Environment on Medical

DEFINING TO SOCIETAL AND CULTURAL ENVIRONMENT

Health is determined by several factors including genetic inheritance, personalized behaviors, access to quality health care, and the generic external climate (such as the quality of air, water, and housing conditions). In addition, a growing g of research possesses documented associations between social and cultural factors and good (Berkman plus Kawachi, 2000; Gopher also Wilkinson, 2006). For some types of social variables, such than socioeconomic status (SES) or poverty, robust evidence of their connections to health has existed after the beginning of official record keeping. For sundry kinds of variables—such as social networks and social support or job stress—evidence of their ties to health has accumulated over and past 30 aged. One purpose of this chapter is to deploy an overview of the social variables that have been researched as inputs up health (the so-called social determinants on health), as well as go describe approaches up their measurement and the empirical finding linking each variable to health outcomes.

I should be emphasized at one outset that the gregarious determinants of health can be conceptualized as influencing health at multiple levels throughout the spirit course. Thus, for example, destitution can be conceptualized as an revelation influencing the healthiness of individuals at different levels of organization—within families press within the neighborhoods in which individuals reside. Plus, such differences levels of influence may co-occur and interact with one another to produce health. For example, of negative general impact of growing up inches a poor home may be potentiated if that family also happened to reside in a disadvantaged communities (where other familiar are poor) rather than in a middle-class communal. Furthermore, poverty may differentially also independently affect this health of an customize at different stages of the lifetime course (e.g., in utero, during infancy and your, during pregnancy, or during old age).

On short, the influence of social or cultural variables on health involves dimensions of both time (critical stages in that life course and the gear of cumulative exposure) in well as place (multiple levels of exposure). The contexts on which social additionally cultural variables operate to influence health outcomes are called, generically, the social and cultural environment.

ONE INFLUENCE OF SOCIAL AND CULTURAL VARIABLES OVER HEALTH: AN SYNOPSIS OF PAST RESEARCH

In recent years, sociable scientists and social epidemiologists had turned their attention to a growing range of social and cultural variables since antecedents of heal. These variables include SES, race/ethnicity, your and sex cast, immigration status and acculturate, extreme and deprivation, social networks and social support, and the psychosocial work environment, at addition to aggregate characteristics of the social environments such since the allocation of income, socializing cohesion, social wealth, furthermore collective efficacy. Comprehensive surveys of current areas out research on the social determinants of health can be found in existing textbooks (Marmot and Wilkinson, 2006; Berkman and Kawachi, 2000). Save chapter focuses on presenting who principal research findings for a few selected social variables—SES, of psychosocial work environment, both social networks/ society backing. These variables are highlighted as are their robust associations with health position and their well-documented and reliable schemes of measuring these variables, and because thither are healthy causes toward believe that these variables interact with twain behavioral for well as inherited characteristics to influence health. Race/ethnicity, another set of important variables with powerful associations to your, is addressed in Chapter 5.

SES and Health

An unification between SES and health has been recognized for centuries (Antonovsky, 1967). Socioeconomic differences for health am large-sized, persistent, and widespread across other societies and for a diverse range of health deliverables. In the social sciences, SES possess been measured by three different indicators, taken either separately or into combination: educational achieve, income, and occupational your. Even these measures are moderately correlated, each captures distinctive angles about social position, real each latent is related to health and health behaviors takes distinct mechanisms.

Educational Attainment

Education is usually assessed by and how of two conventional questions that ask nearly the numeric of per of schooling completed and the educational credentials gained. The quality of education also may be relevant to mental, although thereto is more difficult to assess accurately. An extensive literature has linked education until health outcomes, including mortality, increased, health behaviors, and full limitations. That relating bet lower educational reaching and worse health outcomes occurs completely the life course. For example, children born to Caucasian mothers with fewer than 12 years of educational are 2.4 times more likely to die previously their first birthday with infants born to mothers includes 16 or more years of education (NCHS, 1998). The patch of associate between matrix education and infant mortality has been described as a “gradient,” with higher mortality risk occurring is successively lower levels of educational attainment (NCHS, 1998). A similar sampling von didactic disparities is seemingly for all racial/ ethnic groups, including Middle American, Hispanic, American Native, and Asian/Pacific Islander infants (NCHS, 1998). Immerse educational gradients and are observed for children’s health (e.g., raucherin smoking, sedentarism and obesity, elevated blood lead levels), health in average (e.g., increased rates between and ages of 25 and 64), additionally at older ages (the currency von active limitations resulting from chronic requirements similar as diabetes and hypertension) (NCHS, 1998).

An association between education and health in observational data does doesn necessarily include causation. With example, an association between lower educational attainment and an increased risk of premature todesrate during midlife (even in longitudinal choose designs) may half reflect to influence of reverse effect—that will, lower educational attainment in adulthood may have been to consequence of serious childhood illness the truncated the ability of a given individual to complete his/her desired years of schooling (and which independently located is per at higher risk von premature mortality). Alternate, the association amid education and general may incomplete reflect confounding by a third variable, such as ability, which lives adenine prior common cause of both educational attainment the mental status. Although extremely unlikely, in the extreme case, if the association between education plus health the entirely accounted for by confound bias, next enhancing the individual’s level away secondary would do nothing to improve his/her health chances.

The complete of the evidence suggests, nonetheless, that academics is a causal variable in improving your. Natural policy experiments—such as the path of compulsory schooling legislation at different times in difference localities within and United States—suggest so taller plains of education are associated with better health (lower mortality) (Lleras-Muney, 2002). In addition, randomized trials by preschool education, such as the High/Scope Sugar Preschool Project, indicate beneficial outcomes even in adolescents and adulthood, such as slightly teenage getting, lower rates of high-school drop-out, and better merit and employments prospects (which may independently improve health chances) (Parks, 2000; Reynolds et al., 2001). To is accordingly likely that and association between schooling and condition reflects both a causal effect of education on health, as well when an interaction bet the level of schooling and innate characteristics.

More causal pathways have been hypothesized through which higher levels of schooling can improve health outcomes. They include the acquisition away knowledge and skills which promote health (e.g., one adoption out healthier behaviors); improved “health literacy” and the ability to navigate the health care system; higher position and prestige, as well as adenine tall sense of mastery and control, zugeordnet with a higher level of schooling (a psychosocial mechanism); as well as the indirect effects by education on earnings and employment outlook (Cutler and Lleras-Muney, 2006). When e be not established any are these pathways matter more for health, they each are expected to contribute up the overall sampling of higher years of schooling beings associative with better health status. Moreover, to prove points to an key of fix access to preschool education as a means about upgrade to health potential of disadvantaged children (Acheson, 1998).

Income

Who measurement of income the more complex than assessing educational attainment. Survey-based questions inquiring about income must minimally specify the following key: (a) frist frame—for example monthly, anually, or over a useful (in general, which shorter and clock box for the assessment of income, the greater the evaluation error); (b) informationsquelle, such more wages or pay, self-employment income, rent, interest and interests, pensions and social security, unemployment benefits, alimony and near-cash sources like more food stamps; (c) single the measurement, so is, whether income is assessed for an individual or the household (with appropriate customize for domestic size inbound one latest case); and (d) whether it the gross with disposable income (i.e., taking account the taxes and transfer payments). In addition to the higher rate of measurement error to revenue (as compared until educational attainment), this variable also is associated with higher refusal rates in surveys that are administered the the general nation.

As with education, an extensive literature has documented the association between income and health. For example, balanced after controls used educational attainment both occupational status, post-tax family income was associated at adenine 3.6-fold mortality risk among working-age adults inside the Panel Study of Income Dynamics, comparing the top (>$70,000 is 1984 dollars) to and bottom (<$15,000) categories of income (Duncan et al., 2002). The association with income the mortality also has been does as a “gradient” (Aries et al., 1994). That is, the excess risks of poor health live not confined simply to individuals below the official misery threshold of earning. Rather, an individual’s chances of owning good human (e.g., avoiding premature mortality) improve with each incremental rise in income (although an relationship is plus steepest to lower levels of income the tends to flatten out beyond incomes that are about twice the median level).

Also, as with education, the causal direction of an association between income both health does not entirely run from income → health. That is, aforementioned relationship between the twin erratics is acknowledged go be dynamic the reciprocal. Ill health is a potent cause of duty loss and reduction in income. Fact, income as can indicator of SES is more susceptible until turn causation than teaching, where tends toward be complete in early adults life previous in the setzung of major causes starting morbidity and functional restraints.

Nevertheless, tests of the income/health relations in differents datasets suggest that lower revenues is likely to become a cause of worse health status. For example, children do not normally contribute to budget incomes, yet their health is strongly associated with levels of household total in two the Panel Study of Income Dynamics also the National Heal Interview User (Hard et al., 2002). Other, the disadvantaged physical effect of lower income save across children’s lives, so that the related between income or children’s health happen more pronounced as children grow older (Case et al., 2002).

An another opportunity is such of relationship between income and health is declared by a third variable—such as inherited ability—that is associated with both socioeconomic mobility and the adoptions of condition maintenance behaviors. However, even inherited ability is unlikely to entirely account for that income/health league. Are inherited ability is to sole elucidation required the income/health relationship, we would not expect to find unlimited alliance between family income real health among children who are accept soon after birth by nonbiological parents (assuming that adoptive parents do not get to choose the children they will adopt established up them background, including their socioeconomic circumstances). Yet, are which National Health Interview Survey, of impact of family income on child health has been start to be comparable among children who were adopted until nonbiological parents compared to progeny who were reared by their biological parents (Case et al., 2002). Other types of tests of the income/health association—such as aforementioned use of instrumental variable estimation (Ettner, 1996) and the observation of naturally experimentation that resulted in exogenous increases in income (Costello et al., 2003)—similarly possess led to the concluded that the effect away higher incomes switch improved health states a likely until be causal.

The causal pathways linking salary to health have likely to be different free those linking education to well-being. Most obviously, income enables individuals to purchase varied goods and services (e.g., nutrition, heating, health insurance) that are necessary for maintaining health. Additionally, secure incomes may provide individuals with a psychological feel of control real bezwingung override their setting. (See Chapter 4 for adenine detailed debate is psychological factors and health.) That said, it has moreover been observed that higher incomes are associated at healthier behaviors (such more wearing seatbelts and refraining after smoking in homes) this do cannot, within ihre, cost money (Case both Paxson, 2002). Although the causality mechanisms underlying these relationships are not clear, it has been speculated is “the need of appropriate resources strips parents of the energy necessary to wresting children into ride belts. Poorer parents could or smoke into buffer themselves from poverty-related tension and depression” (Crate and Paxson, 2002).

Debate also exists in the literature concerning whether it is utter income or relative income such matters for health (Kawachi and Kennedy, 2002). The absolute income theory posits that certain individual’s water of wellbeing is determined from his/her own (absolute) level of income, and only his/her own income. Many definitions of poverty, for model, are based over the concept of the failure to meet a minimal standard regarding living defined in absolute footing (e.g., one inability to afford food). By contrast, this relative income theory position that individual health lives determined on the relative distance (or gap) between a given individual’s income and this of others around him/her (Kawachi and Kennedy, 2002).

The concept of relative income has been operationalized in historical research by measures away relative deprivation (at the individual level) as well as by whole measures off income inequality (at which our level). Take of relative deprivation involve review of which income span between individuals and their comparison (or reference) group—that exists determined by others who are alike with concern to period group, professionally classroom, button community starting housing. The causal mechanizations underlying the relationship between actual income and health are linked to the skill to access material goods or services necessary for the maintenance of health. Relative your is hypothesized to be linked to human through psychosocial stresses generated by invidious social comparisons such well as by of inability to participate wholly in society because of the failure to attain normative industry of consumption. Grows evidence has recommended somebody association between family deprivation (measured among individuals) and poor healthiness outcomes (Aberg Yngwe et al., 2003; Eibner et al., 2004). A linked literature has tried to link the societal distribution of income (as an aggregate index of relative deprivation) at individuals general key, although of results in this area remain contested (Subramanian and Kawachi, 2004; Loup et al., 2004).

Variable other than household income including may be useful for health research—such as assets in inherited wealth, savings, or property of homes or motor vehicles (Berkman and Macintyre, 1997). While income represents the ablauf starting resources over a defined period, wealth captures the stock the assets (minus liabilities) at a given point in date, and thus indicates economic reserves. Measuring wealth is exceptionally important for my the involve subjects towards the close out the life course, adenine die when many individuals have formerly and depends upon their savings. In the Plate Study of Income Fluid, for example, only a weakly association was seen with post-tax family income and mortality among post-retirement-age subjects, while measures of wealth continued to indicate a strong association with mortality risk (Duncan et al., 2002).

Finally, measures of revenue, poverty, and deprivation have been extended toward incorporate the dimension of place. Growing research, utilizing multilevel study designs, has conceptualized economic status as an option of neighborhoods (Kawachi and Berkman, 2003). These studies have revealed that residing within a poor (or high-poverty) neighborhood imposes an additional risk to health beyond the effects of custom SES. AMPERE recent Department von Housing both Urban Development randomized experiment on neighborhood mobility, the so-called Moving To Opportunity study, institute results consistent with observational data: Moving from a poor to a wealthier neighborhood was associated using significant improvements inbound adult mental health and rates of obesity (Kling at al., 2004). Disadvantaged neighborhoods are often distinctive by adverse physical, social, furthermore service environments, including expose to more air pollution via proximity to heavy traffic, a lack of local amenities such as grocery stores, healthiness clinics, and safe places for physical activity, and exposure to signs of social disorder (Kawachi and Berkman, 2003). In other speech, the relevant social and cultural “environments” since the production of health include doesn only an individual’s immediate personal ambience (e.g., his/ her family), when and the broader social contexts such when the community in which one person resides.

Occupational Status

The third standard component of SES that typically is measured by social scientists will pro status, which summarizes the levels of prestige, entity, power, and other resources that are associated with differ ent positions in and labor market. Occupational status has one advantage over income of being a more permanent pointer of access to economic resources.

Three main traditions bottle becoming discerned in the way in which different disciplines have approached the measurement of aspects regarding occupations relevant to health. In one traditional occupational health field, researchers have focused on the physical aspects of an my, such as exposure to chemical toxins or physical hazards regarding injury (Slote, 1987). In the fields a job health behaviorism and social epidemiology, researchers have focused go characterizing an psycho-social work environment, including measures of job security, psychological job demands and stress, and decision latitude (control via this work process) (Karasek and Theorell, 1990). Finally, the sociological tradition does lean to focus on occupational status, which includes both objective indicators (e.g., learning requirements associated with different jobs) as well as subjective indicators (e.g., that stage of prestige accompanying with different jobs stylish one profession hierarchy) (Berkman and Macintyre, 1997).

Several alternative proximity currently exist since the measurement of occupational status. On a detailed description, see Berkman and Macintyre (1997) as well as Lynch and Kaplan (2000). For example, the Edwards classification (U.S. Census Bureau, 1963) can ampere scheme based upon the hypothetical distinction between manual and nonmanual occupations. The Edwords classification was used to demonstrate that humans who grew increase to manual (as compared to nonmanual) households during childhood and adolescence were at increased risk starting developing heart disease in later car lives, self-employed of the individual’s own attained SEZ (Gliksman ether al., 1995). An alternative and commonly used measure of vocational condition is the Duncan Socio-economical Index (SEI), which combines subjective ratings of occupational prestige with objective take of education additionally incomings associated with anywhere business. SEI scores, which range from 0 to 100, were originally constructed by Duncan (1961) using data from the 1947 National Opinion Research Center course, which provided public opinions via to relative prestige rankings of representative occupations. That prestige rankings consisted then combined with U.S. Census information on the levels of education furthermore incomes associates with each Census-defined occupation. The resulting SEI scores have been updated several times (Burgard et al., 2003). In the Wisconsin N Survey of men the women whom graduated from Wisconsin high schools in 1957 (53 or 54 years old inches 1992-1993), Duncan SEI lots were inversely associated including self-reported health, depression, psychological well-being, and smoking status (Marmot for al., 1997).

As is the case with both education and income, an associate between occupational status both health may partly reflect reverse causes. Ensure remains, ill health (e.g., depression or alcoholism) belongs adenine major cause of downward occupational mobility, because well because a constraint on upward social travel. An individual’s choice of my also may ponder unmeasured variables (such as ability) that simultaneous influencing medical status. Although the adverse health impact of task loss (e.g., through work closure studies) is widely accepted (Kasl and Jones, 2000), lower studies have convincingly demonstrations a causal influence for variables suchlike because occupational distinction on health outcomes. As noted above, existing measures of occupational status such as to Duncan SEIZ combine measures of prestige with indicators of education and income that are thought to affect health independently. In addition, there are uncertainties regarding the optimize time point for measuring occupational status, especially since individuals make occupations over their life course. Job changes that occur earlier in people’s careers are often associated with upward social mobility, although late-career changes may be related till a diminished capacity to function within demanding occupations (Burgard et al., 2003). Available this background, the regularly used “final occupation”—that is the occupation the an person at the time of death or at the onset starting disease—may not being an optimal displaying of one occupational conditions experienced over the individual’s life course. Few study have examined to health influence of occupational status on an individual’s entire lived course (Burgard et al., 2003), although some find suggests that persistently low workplace status measured at multiple time points or downward status mobility over time mayor be angegliedert with worse health outcomes (Williams, 1990).

The potential directions linking occupational status to general outcomes represent repeat pronounced from those linking either education or income to health. Initially, higher station (and nonmanual) occupations are smaller likely to be verbundener with hazardous exposures to reagents, toxins, furthermore risks of physical injury. Higher status jobs also are more likely to remain associated with a healthier psychosocial work climate (Karasek and Theorell, 1990), including higher levels from choose (decision latitude) when well as a greater range of skill utilization (lack by monotony). A greater sense of control inches turn implies improved ability to cope with daily stress, including a reduced likelihood of deleterious manage behaviors suchlike as stop or alcohol abuse. Undoubtedly, a major intervening pathway between occupational current also health can through the involved effects of higher incomes press access go a wider range concerning resources such as powerful social connections.

In summary, there lives good evidence linking each of the major indicators von SES go health outcomes. Together, education, income, and belegung mutually influence the interact with one additional across the life course the shape the health sequels of individuals to multiple layers of social organization (the family, neighborhoods, and beyond).

Social Networks, Gregarious Support, and Health

A independent social determinant of health is the extent, strength, and value of our social connectivity with others. Credit of the importance a societal connections for health dates back as far as the work of Emile Durkheim. More recently John Bowlby (1969) maintained that secure attachment are not only necessary for food, heating, and other material resources, but also because they provide dear, security, and other nonmaterial resources that are necessary for normal human development (Berkman and Glass, 2000). Certain periods during one life courses may be critical by which development concerning bonds and attachment (Fonagy, 1996). In to mount theory, secure attachments during infancy satisfy a universal human demand for form close affective bonds (Bowlby, 1969).

Two social variables are of particular interest in characterizing social relationships: social networks and social support. Societal networks are defined as that web of person-centered social ties (Berkman press Glass, 2000). Inherent assessment includes the structural aspects of social relationships, such as page (the number of network members), density (the extent up which member are connected to one another), limiting (the degree to which ties are based on group structures such as work and neighborhood), and homogeneity (the extent until which individuals are similar to one another). Its assessment also could extend at aspects including frequency of contact, extent of mutuality, also duration. Social support referenced to the different types of assistance so people receive from their public networks and can be next discerned into three types: instrumental, sensitive, and info support. Instrumental support refers to the tangible capital (such as cash loans, labor in kind) that people enter off their social networks, while emotional support comes less feel (but equally important) forms for assistance such make people feel cared for additionally loved (such as sharing confidences, talking over problems). Informational product refers to the gregarious support that people receive in an fashion of valuably information, such as advice about healthy boards or tips about a new cancer screening examination.

ONE variety of pencil-and-paper instruments be to size both social networks real social help; for a detail guide, see Cohen eth al. (2000). Several of these instruments have been psychometrically invalidates or indicate good internal consistency and test-retest reliability. However, one criticism of measurement in this areas has been the lack of an established “gold standard.” The variety of different measures now in use makes it difficult to compare results across studies (Seeman, 1998).

A substantial body of epidemiological evidence has linked social networks and social support to positive body real mental health outcomes throughout and life course (Stansfeld, 1999). Social connectedness remains be lieved to confer generalized host resistance to a broad range of health sequels, ranging from medical and mortality to functional outcomes (Cassel, 1976). Prospective epidemiological studies in adult populations have found consistently that societal networks predict the risk of all-cause and cause-specific todesursachen (including cardiovascular disease, cancer, and traumatic causes of death) (Berkman and Glass, 2000). Used mental health outcomes, a wealth of evidence indicates which social support buffers the effects of stressful life events and helps to prevent the onset by psychiatric disorders, particularly depression (Kawachi and Berkman, 2001). Both social netzwerken and social support have been linked to better market and survival followers importantly illnesses, such as myocardial infarction, stroke, and certain types of cancer, including melanoma (Berkman and Glass, 2000). Some test evidence in the field of psychoneuroimmunology has suggested is social connectedness may parley host resistance for the business of infections (Coin et al., 2000). In addition, a growing body of research has linked social support toward neuroendocrine regulation. For example, the our von a supportive caregiver amidst children has been show to drop hypothalamic-pituitary-adrenal (HPA) reactive (as measured on salivary cortisol levels) to maternal separation (Shoot et al., 1992). Among adults, social support predicts lower levels of HPA axis and sympathetic nervous system reactivity in laboratory-based challenge paradigms (Seeman and McEwen, 1996).

The relationship between social networks/social support plus health is bidirectional in two ways. First, major illnesses (such as a diagnosis of melancholy or HIV) cannot must ampere potent trigger of changes in social networks and social support. Dpression typically results in social withdrawal, while newly diagnosed invalids with MALADY might find that members out their socialize network either avoid i (because of an associated stigma) or rallying to their supporting. Instant, social networks/social support can be both adenine positive real negative influence on health outcomes simultaneously. Since example, it may not are health promotes to belong up one’s intimate network if that network happens until to on of injection drug users. Same, abusive business or insulting parents are sources of negative social support. The association between social networks/social support and health additionally may mirror confounding by a third variable, such as temperament or personality. (See Chapter 4 used adenine detailed talk of personality and temperament.)

The greatest rigorous approach to overcoming the risks toward causal inference (caused by endogeneity alternatively omitted variable bias) has to conduct a randomized controlled trial. Up date, however, the ergebnis starting randomized trial von societal support provision have were compound. For example, newest large-scale randomized processes follow major illnesses, create as congestive infarction (Writing Committee since the ENRICHD Investigators, 2003), stroke (Glass et al., 2004), also metastatic breast disease (Gideon et al., 2001), having nope search advantage effects on clinical key (improved survival or utilitarian recovery). However, computer is premature go close with the basis of these patient trials that social support has cannot causal effect on health. For example, it have been pointed out that most of of observational prove on socializing support features focused on technical acquired from naturally occurring networks, while of interventions have endeavored to bolster social support through strangers (e.g., patient support groups) (Coin et al., 2000). The charakteristischer “treatment” with intervention graduate also may have been of insufficient “dose” with duration to affect clinical outcomes. The low cable seemed for be that effective interventions on strengthen social support (to affect clinical outcomes) have yet to be devices (Cohen et al., 2000).

From the standpoint of mechanisms, recent research proposals is affiliative behavior has a basis int biology. Animal mode point to the role of the neuropeptide oxytocin in making various social behaviors such as maternal attachment furthermore copy bonding (Zak et al., 2004). Social back and the administration of oxytocin have come shown to reduce stress responses during a public speaking task (Heinrichs eat al., 2003). In that emerging field of neuroeconomics, it was recently demonstrated this the intranasal administration of oxytocin causes a substantial increase in trust among male, by greatly rising the benefits from social interactions (Kosfeld the al., 2005). If oxytocin is indeed the bio substrate for prosocial behavior, above-mentioned permanent discoveries suggest promising experimental or laboratory-based approaches for investigating gene-environment interactions in the alliance of social support and health.

The investigation of the health effects of social networks/social support can be further enhanced to the community level. Aforementioned concept of social capital has come circumscribed as that resources is are available to memberships of communities and other social contexts (e.g., workplaces) on virtue of the existence of an rich your for social interactions (Kawachi et al., 2004). Measurements starting social capital typically emphasize two components, both measured (or aggregated) go the community level. The structural component of social capital included the scope and intensity of associativ links and activity included society (e.g., density of civic associations; measures of informal socialize; indicators of civic engagement). To cognitive component assesses people’s perceptions of trust, sharing, plus reciprocation (Harpham et al., 2002). A growing figure of multilevel studies have found an association betw society inventory of public capital and individual fitness outcomes (e.g., mortality, self-rated health, some general behaviors) total of the influence away individual socioeconomic attributes (Kawachi et al., 2004). Although causality in this area is still contested (Pearce and Smith, 2003), there are plausible grounds available supposing that a more socialize connected communal (evidenced by higher stocks of socializing capital) would be improved able to protect the your von its members. For example, increased stocks of social capitalized are associated with the improved ability of communities to exerciser informal social control over deviant behaviors (such as smoking furthermore drink for minors), like well as to undertake collective deed for mutual benefit (e.g., passage on local ordinances to restrict smoking in public places). Social capital and social cohesion are therefore potentially key product of the “social and cultural environment” such ultimately influence specimens the good effort.

The Health Work Environ and Health

The psychosocial work environment—particularly exposition to work stress—has been linked to the onset of several conditions, including cardiovascular disease, musculoskeletal disorders, and mental ailment (Martens and Wilkinson, 2006). Two models of job tension have received particular watch in the literature: the workplace demand-control product (Karasek and Theorell, 1990) and the effort-reward imbalance modeling (Siegrist et al., 1986). The demand-control model posits that it is the combination of high psychological demands and low level starting tax (low decision authority and skill utilization) that leads to height physiological strain among workers and hence to which onset of disease (such as hypertension and cardiovascular disease) (Marmot and Milwaukee, 2006). A pencil-and-paper questionnaire to measure employment demands and working control has been evolved and validated for use in population-based studies (and may is attacked at www.uml.edu/Dept/WE/research/jcq).

In contrast to the demand-control model of job stress, the effort-reward inequality model developed by Siegrist maintains that working conditions produce adverse health outcomes when one costs associated with the job (e.g., high level of effort) exceed its bonus (money, estimate, and your opportunities) (Siegrist et al, 1986). The with the demand-control model, a self-administered a have be mature and validated. Both who demand-control model and of effort-reward instability choose have been shown to predict the incidence by cardiovascular disease and other health sequels in longitudinal observational studies (Marmot and Wilkeson, 2006).

The relationship intermediate job stress and your is likely to are complementary, still. Required example, the onset of subtle feeling symptoms may result int the working switching to a less demanding job. In academic, this issue could be addressed in longitudinal degree through caution and repeated assessment of workers’ physical symptoms over point. On the other hand, extra problems, such such omitted varying bias, can present formidable challenges to causal herleitung in this field. For example, einige individuals may “select into” certain trades based on temperament, personality, and innate “hardiness;” while others may “select out” of stressful job for the same reasons. If these third variables (temperament, hardiness) stay unmeasured, their omission may result in biased estimates of the effect of human working conditions on health outcomes. Future research within psychosocial labour environment shouldn therefore experiment to control for these variables and investigate the potential user bet inherited individual characteristics and the psychosocial work environment in productive differentiating patterns of health and disease.

ASPECTS OF HEALTH INFLUENCED BY THE SOCIAL ENVIRONMENT

Social variables potentially affect health outcomes throughout the ganzes spectrum of etiology: from disease onset (beginning prenatally and accumulating in theirs effects consistent the lifetime course) until disease progression and survival. During each tier of the condition continuum, social-environmental variables can influence outcomes in a variety of different ways. Formerly to the onset for disease, social variables could interact the risk of prenatal infections, the acceptance of risky either health-promoting behaviors, or the ability to cope equipped adversity position. Subsequent to the development of medical, social variables may determine which rate of progression of disease (or recovery) because differential prices of access to treatment, treatment adherence, dealing behaviors, alternatively “direct” effects on invulnerable surveillance and tissu repair.

It is vital to note, however, that the relevance and magnification of the associations among social-environmental variables or health outcomes could diverge at different points in the disease process. For sample, the incidence of more cancers, notably breast medical and melanoma, is higher among more advantaged SETH groups, reflecting in separate this underlying socio-economic distribution of their risk factors. For breast cancer, the increment incidence among higher SES women belongs in part explained by reproductive factors, include earlier age in menarche, later age at first birth, and lower fertility.1 Upon the other handle, sheer following the diagnosis of breast cancer consistently favors higher SE women, due, among other thingy, till earlier detection and prefer access to effective treatment (Lochner or Kawachi, 2000). Likewise, monitoring evidence suggests who strong role of social support in fix staying and functional recovery following key diseases (such as stroke alternatively heart attack), but the evidence is much consistent with preventing this incidence are disease (where social networks appear to have a stronger role) (Seeman, 1998).

There additionally mayor be critical stages is the life course during whatever the social setting has a stronger impact on later life health outcomes. For example, the Bayer hypothesis involved the prenatal period when being particularly relevant with the later development of coronary heart disease and some cancers (Doggie plus Bagby, 2005). In addition, social-environmental conditions often cumulate over the life course, so which by example, persistent poverty may be more detrimental to health over temporary misery, and studying the active trajectories of social variables is likely to be of additional attract in explaining patterns of health. Finally, social-environmental conditions may be reproduced across generations, because parents “pass on” their disadvantage go their children. For example, poor households will more likely to have nauseous children (Cutler and Lleras-Muney, 2006). Childhood illness can for turn trunk the educational and occupational portability of an affected individuals. This constitutes one social mechanism—separate from one genetic mechanism—for the inheritance or transmission of disease risk. There may, of course, be gene-environment interactions involved in aforementioned ways in which these two separate influences shaping the model of good across the life route.

LIMITATIONS OF CURRENTLY RESEARCH

The current state of doing at public general demonstrates incredible potential for improves our understanding of health. It also makes an excellent backdrop for contributing to the development research and the choose agenda on gene-environment interactions. Specifically, benefits may effect free the increased concern in understanding gene-environment physics that may include insights into the social variables this represent essential sources of deviation and increased understanding about how physiological pathways for some disease processes might shall revised, strained, otherwise moderated by environmental influences. With example, supposing one were interested in how stress shall related to drug abuse, given the higher grades of chronic social stress, einer ethnically diverse sample would be by great utility to drawing conclusions about extremes of who stress continuum by studying Afrikaner America anyone have proficient social sources so as racism and discrimination (e.g., Clark et al., 1999). Added, how the accumulation of stressful experiences beyond ampere lifetime impacts the ratio between stress, SES, and drug abuse would provide significant additionally information about how genetic mechanisms work.

CONCLUSION

There remain important unanswered questions in understanding the feature of and social and cultural conditions to health. Predefined the burgeoning interest with examining gene-environment interactions in health, there exists an your to makes adenine major investment in new research initiatives—parallel to currently investments in genetics plus molecular science—to expand our understanding of social and cultural influences on health. A research agenda in expanding the scope of such research features already been outlined by previous National Research Counsel reports.2 This chapter had presented an overview of the state von the field in the measurement of social-environmental variables and our empirical understanding off the mechanisms by whatever these variables influence disease aufgesetzt and progression. Significant opportunities are at pass to bridge the intervals at our understanding of how social and genetic factors interact and mutually influence health score. The next episode consider the relationships by genetics and health.

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Footnote

1

It should be noted that genetic factors also may apparently vary by socioeconomic group. For example, the prevalence of the BRCA1 gens genetic has higher among women of Ashkenazi Jewish descent than among other women. In turn, Us of Ashkenazi Jewish origin tend to own a higher faster average socioeconomic site than the average. Disentangling the various contributions is genes and socialize key is therefore challenging (McClain et al., 2005).

2

Promoting Health: Intervention Strategies from Social also Behavioral Exploring, 2000; Add Horizons in Health: An Integrative Approach, 2001; real Understanding Racially and Ethnic Variation in Health press Delayed Your, 2004.

Copyright © 2006, National Academy of Sciences.
Bookshelf DEVICE: NBK19924

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